betacoronavirus – Communicable Diseases Research

Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19

코로나19 중증도에 따라 항체 표적 SARS-CoV-2 에피토프 레퍼토리 달라

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 진단, 치료법,

[키워드] antibodies antibody Antigen association Asymptomatic asymptomatic individual asymptomatic infection Betacoronavirus betacoronavirus Community convalescent correlated COVID-19 COVID-19 severity develop diagnosed diagnostics disease severity domains Epitopes Evidence evidence of finding FIVE five groups HKU1 Hospitalization IgG IgGs Immunity immunogenic immunogenic peptide individual Infection less MERS-CoV nucleocapsid protein Nucleocapsid proteins OC43 participant pathogenic pathogenic mechanisms peptide peptide array peptides pilot study predicted Protein RBDs reaction Receptor binding domain Region repertoire SARS-CoV RBD SARS-CoV RBDs SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes seroconverted Seroprevalence seroprevalence. severity severity of COVID-19 symptomatic symptomatic COVID-19 symptomatic infection therapeutic therapeutic antibodies Vaccines Viral with COVID-19 without symptoms
[DOI] 10.1080/21505594.2022.2073025 PMC 바로가기 [Article Type] Article

Mechanisms of host type I interferon response modulation by the nucleocapsid proteins of alpha- and betacoronaviruses

알파 및 베타 코로나바이러스의 뉴클레오캡시드 단백질에 의한 숙주 유형 I 인터페론 반응 조절 메커니즘

Review

Published on 2022-10-012022-09-11
Journal: Archives of Virology
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha animals Antiviral antiviral responses betacoronavirus cause coronavirus Coronavirus infections COVID-19 pandemic Critical diarrhea epidemic diarrhea facilitate Fatality rate function genomic RNA Health Host Human humans initial innate immune response involved knowledge modulate modulation Neonatal nucleocapsid protein Nucleocapsid proteins PEDV Replication responses responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown Signaling type I interferon viral genomic RNA Viral RNA virions virus Virus-host interactions
[DOI] 10.1007/s00705-022-05513-8 PMC 바로가기 [Article Type] Review

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Article

Published on 2022-09-192022-11-15
Journal: PLoS Pathogens
[Category] SARS, 치료제,

Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity

Article

Published on 2022-09-072022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 진단, 치료기술, 치료제,

Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

Article

Published on 2022-08-052022-10-06
Journal: Science (New York, N.y.)
[Category] SARS, 조류인플루엔자, 진단,

Distinct Antibody Responses to Endemic Coronaviruses Pre- and Post-SARS-CoV-2 Infection in Kenyan Infants and Mothers

케냐 유아와 산모의 SARS-CoV-2 감염 전 및 후 풍토성 코로나바이러스에 대한 독특한 항체 반응

Article

Published on 2022-07-122022-09-12
Journal: Viruses
[Category] COVID19(2023년), MERS, SARS, 진단,

SARS-CoV-2, SARS-CoV, and MERS-CoV encode circular RNAs of spliceosome-independent origin

SARS-CoV-2, SARS-CoV 및 MERS-CoV는 spliceosome-independent origin의 원형 RNA를 인코딩합니다.

Article

Published on 2022-07-012022-09-11
Journal: Journal of medical virology
[Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplified Analysis analysis approaches assays Autoimmune disease Autoimmune diseases betacoronavirus betacoronaviruses breakpoint canonical Chain Reaction characterized Circular circular RNA complementary coronavirus Critical cytoplasmic demonstrated distribution Features Fluorescence highlight homologous Host In situ hybridization infected Vero E6 cells junction mechanism MERS-CoV Middle East Middle East respiratory syndrome Coronavirus N gene not limited offer polymerase chain polymerase chain reaction predicted probe respiratory syndrome coronavirus RNA RNA Biology RNA genome RNA genomes RNA sample RNA samples RNA synthesis RNase SARS-CoV SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus transcriptional regulatory sequences Transcriptome Vero E6 VERO E6 cells viral pathogenesis viral transcriptome Virology Virology.
[DOI] 10.1002/jmv.27734 PMC 바로가기 [Article Type] Article

IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes

뚜렷한 계절성 코로나바이러스-보존 SARS-CoV-2 스파이크 하위 도메인을 표적으로 하는 IgG는 차별적인 COVID-19 질병 결과와 상관관계가 있습니다

Article

Published on 2022-05-312022-09-11
Journal: Cell Reports
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제,

[키워드] Activation ADE amplification anti-Spike IgG anti-spike IgG levels anti-spike IgG response Anti-spike IgG responses antibody antibody-mediated effector responses Betacoronavirus betacoronavirus betacoronaviruses caused conserved convalescent individual coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 severity CoVs CP: Immunology CP: Microbiology cross-reactivity Deleterious disease disease severity Early detection epitope Epitopes Fc-gamma receptor activation FcγR fusion protein fusion protein region greater heptad repeat heptad repeat region human betacoronavirus human betacoronavirus. humoral IgG IgG responses immunodominant epitope immunology lowest memory response Microbiology observé OC43 offer outcome predict profile Protective recall receptor responses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS1 seasonal coronaviruses severe COVID-19 patient severe COVID-19 patients severe disease significantly Spectrum Spike protein the SARS-CoV-2 virus β-CoVs
[DOI] 10.1016/j.celrep.2022.110904 PMC 바로가기 [Article Type] Article

Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses

임상적으로 승인된 약물인 Acriflavine은 SARS-CoV-2 및 기타 베타 코로나바이러스를 억제합니다.

Article

Published on 2022-05-192022-09-11
Journal: Cell chemical biology
[Category] COVID19(2023년), SARS, 신약개발, 치료제,

Sequence determinants of human-cell entry identified in ACE2-independent bat sarbecoviruses: A combined laboratory and computational network science approach

ACE2 독립적인 박쥐 사베코바이러스에서 확인된 인간 세포 진입의 서열 결정인자: 결합된 실험실 및 컴퓨터 네트워크 과학 접근

Article

Published on 2022-05-012022-09-12
Journal: EBioMedicine
[Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] ACE2 ACE2 binding Allen approach bat betacoronavirus binding Cell cell entry chimeric coronavirus Culture determinant Entry assay Evidence global health host protein human cell human cells include independent infect infect cells Laboratory majority mammal mapped mathematical model motif mutations Pathogens phenotype phenotypic predicted pseudotype putative receptor Receptor binding domain sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 School screened sequence sequence similarity network similarity spike Spike protein state supported university utility viral entry virus Washington zoonosis. zoonotic
[DOI] 10.1016/j.ebiom.2022.103990 PMC 바로가기 [Article Type] Article